Ann. Pak. Inst. Med. Sci. 2013; 9(3): 159-163

Abstract

Objective: To evaluate effect of oral Celecoxib 100 mg in terms of mean VAS as preemptive analgesic agent in orthopaedic patients undergoing major lower limb surgery by comparing with placebo.
Study Design: Randomized controlled trial.
Place and Duration: The study was conducted between April 2008 to October 2008 in the Department of Orthopaedic Surgery at Pakistan Institute of Medical Sciences Islamabad.
Materials and Methods: In this study, 80 patients undergoing major lower limb surgeries were divided in two equal groups; 40 patients in group A received Celecoxib 100 mg 40 minutes before surgery and while 40 patients in group B received placebo 30 minutes before surgery. Comparison of two groups was done for mean visual analogue score (VAS) on first postoperative day at 6 am. T-test was applied for statistical difference (p-value <0.05 was taken as significant).
Results: The mean VAS group A was 4.24 ± 1.097 and in group B was 8.13 ± 1.017. p-value was 0.000 (statistically significant)
Conclusion: The Celecoxib, as preemptive can significantly reduce the postoperative pain score as compared to placebo analgesic in major lower limb orthopaedic surgeries.
Key Words: Celecoxib; preemptive analgesic; visual analogue score.

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